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Neoadjuvant nivolumab plus platinum-based chemotherapy conferred sustained clinical benefit for patients with resectable non-small cell lung cancer, 3-year follow-up results of the phase 3 CheckMate -816 trial showed. Researchers observed the benefit with nivolumab (Opdivo, Bristol Myers Squibb), a PD-1 immune checkpoint inhibitor, irrespective of surgical approach or extent of resection, according to updated data presented at European Lung Cancer Congress 2023 and announced in a Bristol Myers Squibb press release. The randomized, open-label phase 3 CheckMate-816 trial evaluated platinum-based ...

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There is no clear agreement on how to handle anticoagulation decisions before minimally invasive glaucoma surgery, according to a speaker at the American Glaucoma Society meeting. Tejus Pradeep, MD, said the literature on anticoagulants in MIGS has been limited, and he and colleagues wanted to find out what glaucoma surgeons thought about the topic. They created an online anonymized survey for AGS members using standard definitions of anticoagulants and antiplatelet agents, as well as six broad definitions of MIGS procedures. Among the 103 surgeons who responded, the most commonly performed MIGS ...

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Patients with androgenetic alopecia demonstrated improvements in hair follicle growth and density after treatment with topical melatonin, according to a study. Melatonin, a pleiotropic hormone, affects the physiological processes including that of the hair follicle, Arash Babadjouni, MS, of the department of dermatology at the University of California, Irvine, and of Midwestern University Arizona College of Osteopathic Medicine, and colleagues wrote. We seek to identify the scientific evidence to support the potential benefits of melatonin in human hair growth. The ...

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Female physicians experienced a greater earnings penalty due in part to marriage and children compared with their male counterparts, according a recent study. Researchers found that female physicians were more likely to be single and less likely to have children than their male counterparts, but still earned less per hour regardless. When female physicians do marry and have children, they experience a steeper earnings penalty because of less hours worked than men. It was the top story in hematology/oncology last week. Another top story was about a study which found that survival for patients ...

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Analyses of blood metabolite profiles showed that people with a history of mental illness had a biological age older than their actual age, according to a presentation at the European Congress of Psychiatry. It is now possible to predict peoples age from blood metabolites, Julian Mutz, PhD, a postdoctoral research associate at the Social, Genetic and Developmental Psychiatry Centre at Kings College London, said in a related press release. We found that, on average, those who had a lifetime history of mental illness had a metabolite profile which implied they ...

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The use of topical corticosteroids to treat atopic dermatitis in infants also may help prevent hens egg allergy, but it may inhibit the babys growth as well, according to a study published in The Journal of Allergy & Clinical Immunology. Before it can be considered for preventing hens egg allergy, the treatment described in this study will need to be modified, Kiwako Yamamoto-Hanada, MD, PhD, chief of the allergy center at the National Center for Child Health and Development in Tokyo, and colleagues wrote in the study. The study enrolled 640 infants aged 7 to 13 weeks ...

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Amivantamab-vmjw conferred long-term clinical response in patients with advanced non-small cell lung cancer and EGFR exon 20 insertion mutations, according to data from the agents manufacturer. Researchers observed the benefit with amivantamab-vmjw (Rybrevant, Janssen), an EGFR and MET bispecific antibody, specifically among patients whose disease had progressed on previous platinum-based chemotherapy. The agent previously received FDA accelerated approval for this indication. The long-term results of the open-label, multicenter, ongoing phase 1 CHRYSALIS study, presented at 2023 ...

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